Neurosteroid; Endogenous, Analgesics
Peripheral sensitisation and central sensitisation are implicated in the development of neuropathic pain with neuroplasticity occurring at multiple levels of the pain pathway. Hypersensitivity of the spinothalamic tract has been described in neuropathic animal models…
Read more A systematic review of therapeutic interventions to reduce acute and chronic post-surgical pain after amputation, thoracotomy or mastectomy
Abstract Background: Perioperative neuropathic pain is under-recognized and often undertreated. Chronic pain may develop after any routine surgery, but it can have a far greater incidence after amputation, thoracotomy or mastectomy. The peak noxious barrage…
Read more COULD THE CONSUMPTION OF SPICY FOODS REDUCE THE PREVALENCE OF CHRONIC PAIN?
Population based cohort study Although there are reasons to be cautious, the recent paper by Lv et al, in the latest edition of the BMJ is interesting and is suggestive of the potential health benefits…
Read more Calcitonin for acute neuropathic pain associated with spinal cord injury
By DR STEPHEN HUMBLE MBChB MSc PhD FCARCSI, Consultant in Anaesthesia and Pain Medicine at Medicolegal Associates Ltd Neuropathic pain associated with spinal cord injury is caused by complex neural mechanisms and is often refractory…
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